Botox injections are generally not very painful, even though some individuals may experience mild discomfort during the procedure. The sensation is usually described as a slight pinch or sting as the needle penetrates the skin. The needles that are used for Botox are very fine, and the injections themselves are quick, minimizing any discomfort. For those individuals with a low pain threshold or anxiety about needles, a topical numbing cream or ice may be applied to the area of injection before the procedure to further reduce any discomfort. Still, most patients find the treatment tolerable, and due to the procedure being quick, any discomfort is brief and subsides rapidly.